AE Biochemistry,
7th Edition

Part I: MOLECULAR COMPONENTS OF CELLS.
1. The Facts of Life: Chemistry is the Logic of Biological Phenomena 1.
2. Water: The Medium of Life.
3. Thermodynamics of Biological Systems.
4. Amino Acids and the Peptide Bond.
5. Proteins: Their Primary Structure and Biological Functions.
6. Proteins: Secondary, Tertiary and Quaternary Structure.
7. Carbohydrates and the Glycoconjugates of Cell Surfaces.
8. Lipids.
9. Membranes and Membrane Transport.
10. Nucleotides and Nucleic Acids.
11. Structure of Nucleic Acids.
12. Recombination, Cloning, Gene Editing and Synthetic Biology--An Introduction.
Part II: PROTEIN DYNAMICS.
13. Enzymes--Kinetics and Specificity.
14. Mechanisms of Enzyme Action.
15. Enzyme Regulation.
16. Molecular Motors.
Part III: METABOLISM AND ITS REGULATION.
17. Metabolism: An Overview.
18. Glycolysis.
19. The Tricarboxylic Acid Cycle.
20. Electron Transport and Oxidative Phosphorylation.
21. Photosynthesis.
22. Gluconeogenesis, Glycogen Metabolism and the Pentose Phosphate Pathway.
23. Fatty Acid Catabolism.
24. Lipid Biosynthesis.
25. Nitrogen Acquisition and Amino Acid Metabolism.
26. Synthesis and Degradation of Nucleotides.
27. Metabolic Integration and Organ Specialization.
Part IV: INFORMATION TRANSFER.
28. DNA Metabolism: Replication, Recombination and Repair.
29. Transcription and the Regulation of Gene Expression.
30. Protein Synthesis.
31. Completing the Protein Life Cycle: Folding, Processing and Degradation.
32. The Reception and Transmission of Extracellular Information.

• Reginald H. Garrett

  Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.

• Charles M. Grisham

  Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.

• Think Pair Share problems encourage readers to work collaboratively to further their understanding of biochemistry concepts.

• Careers in Chemistry features showcase various career paths readers can take after studying biochemistry. Featuring a diverse, inclusive and equitable chemical community, these examples help inspire all readers to see a future for themselves in chemistry-related careers.

• The authors have added over 160 new and revised exercises to the text and online course to ensure content is current and relevant for today's learners.

• Step-by-Step solutions help readers master effective approaches to common and complex problems in biochemistry.

• A number of new and updated Deeper Look and Critical Developments in Biochemistry features expand on key topics or experimental observations while addressing the latest developments in biochemistry, such as human preteome, NMR, Cryo-EM, AlfaFold and CRISPR-Ca-9.

• The text is integrated with OWLv2, a powerful online learning platform for chemistry with text-specific end-of-chapter material to engage readers and improve learning outcomes.

• OWLv2 now includes MCAT Essays and Practice Problems written by members of medical school admissions committees and advisors to help prepare readers for the MCAT exam.

• Over fifty percent of problems in OWLv2 now come with targeted feedback on common errors. This answer-specific feedback explains why the readers' incorrect answers missed the mark and guides them toward the correct solution.

• A new, semester-long Protein Structure and Function Exploration Project invites readers to study a protein and use protein-modeling software to learn biochemistry actively in an in-depth research and writing project.

• Readers can access an online Protein Structure and Function Exploration Library of Proteins and Nucleic Acids (http://www.psafe.us), with over 1200 protein and nucleic acid structures organized by chapters in the text.

• The laddered assessment course template in OWLv2 combines conceptual mastery modules with traditional end-of-chapter questions into one structured learning path, anchoring student learning around one topic at a time, while still being organized at the chapter level.

• Each chapter is framed around an Essential Question to engage readers and encourage curiosity about the subject matter.

• At the end of each chapter, a Foundational Biochemistry feature provides a comprehensive list of the principal facts and concepts that readers should understand after completing the chapter.

• Prepared especially for this book, over 1100 images of prominent proteins and nucleic acids involved with essential biological functions help illustrate and inform chapter content.

• Further Readings sections at the end of each chapter make it easy to find up-to-date information for additional exploration of key topics covered in the chapter.

• Human Biochemistry essays emphasize the central role of basic biochemistry in medicine and the health sciences. These essays often present clinically important issues such as diet, diabetes and cardiovascular health.

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